If you use part of your home exclusively and regularly for business, you may be able to deduct home office expenses. There are two methods: the simplified method ($5 per square foot, up to 300 sq ft) or the regular method (deducting a percentage of actual home expenses). This deduction is only available to self-employed people and business owners — not remote employees. The space must be used only for business, not as a guest room or general-purpose area. Report it on Schedule C (for sole proprietors) or Form 8829.