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A CP49 notice means the IRS has applied your tax refund — either in full or in part — to a past-due federal tax debt you owe. This is called a "refund offset," and the IRS is required to notify you when it happens. If your refund was only partially offset, the notice will also tell you when you can expect the remaining portion of your refund.
The CP49 will identify the tax year and amount of the debt that was satisfied (or partially satisfied) by the offset. For example, if you were owed a $3,000 refund but owed $1,200 in back taxes from a prior year, the IRS offsets $1,200 against the debt and sends you the remaining $1,800 — and issues a CP49 explaining what happened.
If you agree that you owe the debt and the offset is accurate, no further action is needed. The offset reduces (or eliminates) your prior balance, and any remaining refund will be issued normally. However, if you believe you don't owe the debt being collected — or if you believe the offset was applied in error — you should contact the IRS using the number on the notice. If you're part of a joint return and the debt belongs only to your spouse, you may be able to file an Injured Spouse Allocation (Form 8379) to recover your share of the refund, as long as you file it promptly after receiving the notice.
Note that refund offsets can also be triggered by non-IRS debts — student loans in default, child support arrears, state income taxes, and unemployment compensation overpayments are all common reasons for refund offsets handled through the Treasury Offset Program (TOP). In those cases, the CP49 comes from the IRS but the debt itself is held by another agency, and you'd need to contact that agency directly to dispute or resolve the underlying obligation.