Botox and other cosmetic treatments are popular, but they generally do not qualify as medical deductions unless there is a medically documented reason for the procedure. Cosmetic treatments performed purely to improve your appearance, such as Botox for wrinkles, are not deductible medical expenses under IRS rules. However, if Botox is prescribed by a doctor to treat a medical condition such as chronic migraines, excessive sweating, or muscle spasms, it may qualify. The distinction the IRS makes is between treatments for appearance and treatments for a diagnosed medical condition. Performers, models, and entertainers have sometimes tried to deduct cosmetic procedures as a business expense, but the IRS and courts have generally rejected that argument.